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This new year will be filled with milestones, including America’s 250th birthday, the world’s greatest sports competitions and a mission to the moon.

From GLP-1 clinical trials to new advancements for breast cancer, NBC medical contributor Dr. Natalie Azar joins TODAY to discuss the medical innovations set to shape 2026.

Russia launched more than 200 drones at Ukraine as new year struck, while Putin and Zelenskyy offered messages to their nations.

New York City Mayor Zohran Mamdani hosted an inauguration at New York’s City Hall, saying his administration “begins a new era,” adding that his government will be “of New York, by New York and for New York.”

About 40 people were killed and more than 100 injured after a fire broke out at a bar at a popular Swiss Alps ski resort town on New Year's Eve, according to police. The president of the Swiss Confederation, Guy Parmelin, said that many of the victims were young people and include Swiss residents as well as tourists from neighboring countries and elsewhere.

Local officials say the death toll could rise as seven people are missing following the attack on New Year's Eve.

Gambian authorities say 96 people rescued after boat capsizes along popular West African migration route.

By the end of his second term, Trump will be the oldest sitting president in US history, though he denies slowing down.